I got very excited about Wises after my game at BWHQ where I played a Noble Bastard Duelist with Family Secrets-Wise.
So at the beginning of my session last night I reminded the players about Wises (everyone in the game is new and it was only our 3rd session) and made sure I knew what the Wise was for each character. For the players who didn't have one I encouraged them to start thinking about opening one up.
The players responded enthusiastically and we had several tests throughout the evening. By the end, between the four characters we had four Wises: Bard-Wise, Assassination-Wise, Dire Forest-Wise, and Kansk-Wise and the tests really helped the setting come to life and also introduced some new complications to the Big Story of trying to find several missing elves, including my father's elf's one true love.
Well into the session, through, I noticed, though, that the players were using Wises to create NPC's.
Then I suddenly asked myself, "Wait, isn't that what Circles tests are for?" Maybe you can't create an NPC with a Wise. I mentioned this doubt to the players but then said, "Okay, if you create an NPC with a Wise, you'll still have to use Circles if you want to go find this new NPC and to determine his or her disposition toward you."
Then after the session I re-read the write-up on Wises in the Adventure Burner and the example of Village of Hochen-Wise specifically lists "Who's the chief of Hochen?" as an Ob 1 test. So clearly you can discover or create an NPC with a Wise.
So maybe I did everything right, but I thought I'd check here on the forums for any clarifying thoughts on this.